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GLASS

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GPCR

Name	Gamma-aminobutyric acid type B receptor subunit 1
Species	Rattus norvegicus (Rat)
Gene	Gabbr1
Synonym	Gb1 gamma-aminobutyric acid (GABA) B receptor 1 gamma-aminobutyric acid (GABA) B receptor GABABR1 GABAB1 GABA-BR1 GABA-B-R1 GABA-B receptor 1 GPRC3A [ Show all ]
Disease	N/A for non-human GPCRs
Length	991
Amino acid sequence	MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSDVQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
UniProt	Q9Z0U4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2753
IUPHAR	240
DrugBank	N/A

Ligand

Name	flumazenil
Molecular formula	C15H14FN3O3
IUPAC name	ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Molecular weight	303.293
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	1.0
Synonyms	NCGC00025116-01 Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate OFBIFZUFASYYRE-UHFFFAOYSA-N F 6300 Flumazenil authentic 78755-81-4 Flumazenilum [Latin] AB00572626_14 FYP AKOS015888159 HMS3374E10 Biomol-NT_000285 Lanexat CCG-100968 MLS000028850 D02MTS NCGC00015439-03 ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0;{2,6}]tetradeca-1(10),3,5,11,13-pentaene-5-carboxylate SCHEMBL79030 TL8005362 W-5096 Q-201122 Ro15-1788 ethyl 8-fluoranyl-5-methyl-6-oxidanylidene-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate NCGC00025116-04 ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate. PDSP2_001761 40P7XK9392 Flumazenil, >99% (HPLC), solid 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester Flumazil AC-6846 HMS2051D17 AOB5595 HY-B0009 BRD-K98769987-001-12-0 LP00506 CHEMBL407 MLS001424108 DSSTox_CID_3064 NCGC00015439-06 Romazicon (TN) SR-01000075879-1 Tox21_110148_1 ZINC1464 Ro 151788 NCGC00015439-09 ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]-benzodiazepine-3-carboxylate NSC-759193 Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate # Flumazenil (transdermal patch formulation) 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester Flumazenilo [Spanish] AB00572626-12 FT-0630863 AFC-3002 HMS3261F13 BDBM26263 K393 C15H14FN3O3 MCULE-2830706565 CTK8F9785 NCGC00015439-01 DTXSID2023064 SBI-0050490.P002 ST24047162 UPCMLD-DP137 [3H]Ro15-1788 RO-151788 NCGC00025116-02 Ethyl 8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate Opera_ID_1516 F-145 Flumazenil [USAN:BAN:INN] 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester Flumazepil AB00572626_15 GTPL4192 AN-6313 HMS3393D17 BPBio1_001190 Lopac-F-6300 CHEBI:5103 MLS000759529 D0D5GD NCGC00015439-04 ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,11,13-pentaene-5-carboxylate SMR000058450 Tocris-1328 Z1551429735 Ro 15-1788 Roma Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate NCGC00025116-05 Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate Pharmakon1600-01505701 Flumazenil (JAN/USP/INN) 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester Flumazenil, United States Pharmacopeia (USP) Reference Standard A839484 Flumenazil AC1L1FSE HMS2089B15 AS-13923 I01-0379 BRN 4763661 LS-77778 CPD000058450 MolPort-003-666-855 DSSTox_GSID_23064 NCGC00015439-07 s1332 SR-01000075879-3 Tox21_500506 [11C]flumazenil Ro-15-1788 NCGC00015439-11 Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-3-carboxylate NSC759193 EU-0100506 Flumazenil (transdermal patch formulation), Coeruleus 755F814 Flumazenilum AB00572626-13 fumazenil AJ-08034 HMS3267P09 BIDD:GT0766 KS-00000XSM CAS-78755-81-4 MFCD00242764 D00697 NCGC00015439-02 ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0(2),]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate SC-15263 SW197598-2 UPCMLD-DP137:001 Ro-151788000 NCGC00025116-03 ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate PDSP1_001778 F0958 Flumazenil [USAN:USP:INN:BAN] 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester Flumazepil;Ro 15-1788;Anexate;Lanexat;Mazicon;Roma AB2000052 GTPL4367 Anexate HMS3657K11 BRD-K98769987-001-01-3 Lopac0_000506 MLS001076354 DB01205 NCGC00015439-05 ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate SR-01000075879 Tox21_110148 ZB000344 Ro 15-1788/000 Romazicon Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a] [1,4]benzodiazepine-3-carboxylate NCGC00261191-01 Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate Flumazenil (Ro 15-1788) 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8- fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester Flumazenilo AB0014201 FlumUP TD AC1Q33UE HMS2234F06 BCP07573 IMI061 C07825 Mazicon CS-0629 NC00218 DSSTox_RID_76860 NCGC00015439-08 SAM001246763 SR-01000075879-7 UNII-40P7XK9392 [11C]flumazenil (PET ligand) Ro-15-1788/000 [ Show all ]
Inchi Key	OFBIFZUFASYYRE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
PubChem CID	3373
ChEMBL	CHEMBL407
IUPHAR	N/A
BindingDB	26263
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.0 nM	PMID1848629	BindingDB
Ki	1.9 nM	PMID1848629	BindingDB
Ki	2.0 nM	PMID1848629	BindingDB

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