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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Nociceptin receptor
Species	Mus musculus (Mouse)
Gene	Oprl1
Synonym	NOP receptor NOP-r NOPr OP4 ORGC Orphanin FQ receptor NOCIR nociceptin/orphanin FQ receptor nociceptin receptor ORL1 N/OFQ receptor MOR-C KOR-3 kappa3-related opioid receptor Kappa-type 3 opioid receptor K3 opiate receptor XOR1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	367
Amino acid sequence	MESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
UniProt	P35377
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3621
IUPHAR	320
DrugBank	N/A

Ligand

Name	Morphinan-3-ol, 17-(2-propenyl)-
Molecular formula	C19H25NO
IUPAC name	17-prop-2-enyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol
Molecular weight	283.415
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.5
Synonyms	NSC_9036 BDBM92849 CHEMBL608539 Lorfan (Salt/Mix) OZYUPQUCAUTOBP-UHFFFAOYSA-N CAS_152-02-3 L001162 AC1L1GZN SCHEMBL209271 Levallorphan tartrate (Salt/Mix) [ Show all ]
Inchi Key	OZYUPQUCAUTOBP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25NO/c1-2-10-20-11-9-19-8-4-3-5-16(19)18(20)12-14-6-7-15(21)13-17(14)19/h2,6-7,13,16,18,21H,1,3-5,8-12H2
PubChem CID	3912
ChEMBL	CHEMBL608539
IUPHAR	N/A
BindingDB	92849
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	266.0 nM	PMID11546835	BindingDB
Ki	5000.0 nM	PMID11546835	BindingDB

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