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GPCR

NameSomatostatin receptor type 2
SpeciesMus musculus (Mouse)
GeneSstr2
Synonymsomatotropin release-inhibiting factor receptor
SRIF-1
SS-2-R
SS2-R
SS2R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length369
Amino acid sequenceMEMSSEQLNGSQVWVSSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWCVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
UniProtP30875
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3207
IUPHAR356
DrugBankN/A

Ligand

NameBIM-23058
Molecular formulaC62H77N11O10
IUPAC name(2S)-6-amino-N-[(2S)-1-[[(2S)-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanamide
Molecular weight1136.36
Hydrogen bond acceptor12
Hydrogen bond donor13
XlogP4.7
SynonymsCHEMBL3350159
BDBM82459
BIM 23058
D-Phe-L-Phe-L-Tyr-D-Trp-L-Lys-L-Val-L-Phe-L-Thr-NH2
Inchi KeyPJCMWSADNFSZJV-BORIPLSNSA-N
Inchi IDInChI=1S/C62H77N11O10/c1-37(2)53(62(83)71-51(33-41-21-11-6-12-22-41)61(82)73-54(38(3)74)55(65)76)72-57(78)48(25-15-16-30-63)67-60(81)52(35-43-36-66-47-24-14-13-23-45(43)47)70-59(80)50(34-42-26-28-44(75)29-27-42)69-58(79)49(32-40-19-9-5-10-20-40)68-56(77)46(64)31-39-17-7-4-8-18-39/h4-14,17-24,26-29,36-38,46,48-54,66,74-75H,15-16,25,30-35,63-64H2,1-3H3,(H2,65,76)(H,67,81)(H,68,77)(H,69,79)(H,70,80)(H,71,83)(H,72,78)(H,73,82)/t38-,46-,48+,49+,50+,51+,52-,53+,54+/m1/s1
PubChem CID9833424
ChEMBLN/A
IUPHARN/A
BindingDB82459
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki45.7 nMPMID7870182BindingDB
Ki46.0 nMPMID8100350BindingDB

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