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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Trace amine-associated receptor 1
Species	Mus musculus (Mouse)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProt	Q923Y8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4908
IUPHAR	364
DrugBank	N/A

Ligand

Name	CHEMBL3640008
Molecular formula	C16H15ClF3N3O
IUPAC name	5-chloro-N-[4-[(2S)-morpholin-2-yl]phenyl]-4-(trifluoromethyl)pyridin-2-amine
Molecular weight	357.761
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	3.3
Synonyms	US8802673, 82 BDBM129440 SCHEMBL12609876
Inchi Key	DBGUEDAIQPJBQO-CQSZACIVSA-N
Inchi ID	InChI=1S/C16H15ClF3N3O/c17-13-8-22-15(7-12(13)16(18,19)20)23-11-3-1-10(2-4-11)14-9-21-5-6-24-14/h1-4,7-8,14,21H,5-6,9H2,(H,22,23)/t14-/m1/s1
PubChem CID	68325622
ChEMBL	CHEMBL3640008
IUPHAR	N/A
BindingDB	129440
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.8 nM	, None	BindingDB,ChEMBL

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