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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61168
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3427
IUPHAR	215
DrugBank	N/A

Ligand

Name	Tilozepine
Molecular formula	C17H18ClN3S
IUPAC name	7-chloro-4-(4-methylpiperazin-1-yl)-10H-thieno[3,2-c][1]benzazepine
Molecular weight	331.862
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.2
Synonyms	7-chloro-4-(4-methylpiperazin-1-yl)-10H-thieno[3,2-c][1]benzazepine NSC_172286 10H-Thieno(3,2-c)(1)benzazepine, 7-chloro-4-(4-methyl-1-piperazinyl)- BDBM81985 Tilozepina 7-chloro-10-(4-methyl-piperazin-1-yl)-4H-3-thia-9-aza-benzo(f)azulene DTXSID30195074 UNII-3RG8Q831DX NT 104-252 3RG8Q831DX CAS_42239-60-1 7-chloro-4-(4-methyl-1-piperazinyl)-10H-Thieno(3,2-c)(1)benzazepine L001129 ZINC31490523 AC1L58W0 SCHEMBL2110610 42239-60-1 CHEMBL2105484 Tilozepine [INN] [ Show all ]
Inchi Key	SKASXEDXLXEXKN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H18ClN3S/c1-20-5-7-21(8-6-20)17-14-4-9-22-16(14)10-12-2-3-13(18)11-15(12)19-17/h2-4,9,11H,5-8,10H2,1H3
PubChem CID	172286
ChEMBL	N/A
IUPHAR	N/A
BindingDB	81985
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	27.0 nM	PMID2895008	BindingDB

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