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GPCR

NameThromboxane A2 receptor
SpeciesHomo sapiens (Human)
GeneTBXA2R
SynonymTXA2-R
TP receptor
prostanoid TP receptor
DiseaseDiabetic neuropathy
Acute myocardial infarction
Allergic asthma
Allergic rhinitis
Angina pectoris
[ Show all ]
Length343
Amino acid sequenceMWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
UniProtP21731
Protein Data Bank6iiu, 6iiv
GPCR-HGmod modelP21731
3D structure modelThis structure is from PDB ID 6iiu.
BioLiPBL0436517, BL0436516, BL0436518, BL0436515, BL0436513, BL0436514
Therapeutic Target DatabaseT76198
ChEMBLCHEMBL2069
IUPHAR346
DrugBankBE0000759

Ligand

NameCHEMBL280396
Molecular formulaC19H27NO5S
IUPAC name(Z)-7-[(1S,2R,5R)-2-hydroxy-5-[(4-methylphenyl)sulfonylamino]cyclopentyl]hept-5-enoic acid
Molecular weight381.487
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP2.5
SynonymsN/A
Inchi KeyAHIGENLQAMBSQQ-ONJMKARJSA-N
Inchi IDInChI=1S/C19H27NO5S/c1-14-8-10-15(11-9-14)26(24,25)20-17-12-13-18(21)16(17)6-4-2-3-5-7-19(22)23/h2,4,8-11,16-18,20-21H,3,5-7,12-13H2,1H3,(H,22,23)/b4-2-/t16-,17+,18+/m0/s1
PubChem CID44273278
ChEMBLCHEMBL280396
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
CF340.0 -Bioorg. Med. Chem. Lett., (1995) 5:12:1215ChEMBL

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