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Name | Leukotriene B4 receptor 2 |
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Species | Homo sapiens (Human) |
Gene | LTB4R2 |
Synonym | NOP9 12-HHT receptor Seven transmembrane receptor BLTR2 LTB4-R2 LTB4-R 2 [ Show all ] |
Disease | Inflammatory bowel disease |
Length | 358 |
Amino acid sequence | MSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRTTPQLKVVGQGRGNGDPGGGMEKDGPEWDL |
UniProt | Q9NPC1 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9NPC1 |
3D structure model | This predicted structure model is from GPCR-EXP Q9NPC1. |
BioLiP | N/A |
Therapeutic Target Database | T30563 |
ChEMBL | CHEMBL3191 |
IUPHAR | 268 |
DrugBank | BE0003489 |
Name | LY223982 |
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Molecular formula | C30H30O7 |
IUPAC name | 3-[3-(2-carboxyethyl)-4-[(E)-6-(4-methoxyphenyl)hex-5-enoxy]benzoyl]benzoic acid |
Molecular weight | 502.563 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 2 |
XlogP | 5.8 |
Synonyms | CGS-23131 IGF-1 inhibitors, Axelar/Biovitrum LY-223982 SCHEMBL7202044 [3H]CGS 23131 [ Show all ] |
Inchi Key | SYZSSLLFRVDRHL-QPJJXVBHSA-N |
Inchi ID | InChI=1S/C30H30O7/c1-36-26-14-10-21(11-15-26)7-4-2-3-5-18-37-27-16-12-24(19-22(27)13-17-28(31)32)29(33)23-8-6-9-25(20-23)30(34)35/h4,6-12,14-16,19-20H,2-3,5,13,17-18H2,1H3,(H,31,32)(H,34,35)/b7-4+ |
PubChem CID | 6444688 |
ChEMBL | CHEMBL49302 |
IUPHAR | 3415 |
BindingDB | 50001611 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 15.0 nM | PMID1320692 | BindingDB |
Ki | 35.0 nM | PMID1320692 | BindingDB |
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