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GPCR

NamePlatelet-activating factor receptor
SpeciesMus musculus (Mouse)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN
UniProtQ62035
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3993
IUPHAR334
DrugBankN/A

Ligand

NameCHEMBL340544
Molecular formulaC26H25N3O
IUPAC name2-[1-(2,2-diphenylacetyl)piperidin-4-yl]-2-pyridin-3-ylacetonitrile
Molecular weight395.506
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP4.1
SynonymsSCHEMBL9852966
2-[1-(1-Oxo-2,2-diphenylethyl)-4-piperidinyl]-2-(3-pyridinyl)acetonitrile
(1-Diphenylacetyl-piperidin-4-yl)-pyridin-3-yl-acetonitrile
BDBM50003536
Inchi KeyDBKJBAQPDMQAHQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H25N3O/c27-18-24(23-12-7-15-28-19-23)20-13-16-29(17-14-20)26(30)25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-12,15,19-20,24-25H,13-14,16-17H2
PubChem CID10408388
ChEMBLCHEMBL340544
IUPHARN/A
BindingDB50003536
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ID5014.0 mg.kg-1PMID1433215ChEMBL

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