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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameSCHEMBL17418599
Molecular formulaC29H27FN2O4S
IUPAC name(3S)-3-cyclopropyl-3-[3-[[5-(2-fluoro-5-methoxyphenyl)-6-(3-methylthiophen-2-yl)pyrazin-2-yl]methoxy]phenyl]propanoic acid
Molecular weight518.603
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP5.4
SynonymsBBRSWTWQMDNZOI-QHCPKHFHSA-N
BDBM168154
US9688642, 33
(3S)-3-Cyclopropyl-3-(3-((5-(2-fluoro-5-methoxyphenyl)-6-(3-methylthiophen-2-yl)pyrazin-2-yl)methoxy)phenyl)propanoic acid
Inchi KeyBBRSWTWQMDNZOI-QHCPKHFHSA-N
Inchi IDInChI=1S/C29H27FN2O4S/c1-17-10-11-37-29(17)28-27(24-13-21(35-2)8-9-25(24)30)31-15-20(32-28)16-36-22-5-3-4-19(12-22)23(14-26(33)34)18-6-7-18/h3-5,8-13,15,18,23H,6-7,14,16H2,1-2H3,(H,33,34)/t23-/m0/s1
PubChem CID118645402
ChEMBLN/A
IUPHARN/A
BindingDB168154
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC5030.0 nMN/ABindingDB

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