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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Homo sapiens (Human)
Gene	PTGER2
Synonym	PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 EP2 receptor [ Show all ]
Disease	Osteoporosis Pulmonary arterial hypertension Miscarriage Medical abortion Immune disorder Glaucoma Solid tumours Endometriosis Diabetic foot ulcer Cancer [ Show all ]
Length	358
Amino acid sequence	MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProt	P43116
Protein Data Bank	N/A
GPCR-HGmod model	P43116
3D structure model	This predicted structure model is from GPCR-EXP P43116.
BioLiP	N/A
Therapeutic Target Database	T38529
ChEMBL	CHEMBL1881
IUPHAR	341
DrugBank	BE0000368

Ligand

Name	SCHEMBL18357252
Molecular formula	C30H29ClFNO4
IUPAC name	4-[3-[(2R)-2-[(E)-3-[3-(4-chloro-2-methylphenyl)-5-fluorophenyl]-3-hydroxyprop-1-enyl]-5-oxopyrrolidin-1-yl]propyl]benzoic acid
Molecular weight	522.013
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	5.7
Synonyms	BDBM202472 US9540357, example 35 US9540357, example 34
Inchi Key	BBTVQJNBBOHHAH-BUNSPHNPSA-N
Inchi ID	InChI=1S/C30H29ClFNO4/c1-19-15-24(31)8-11-27(19)22-16-23(18-25(32)17-22)28(34)12-9-26-10-13-29(35)33(26)14-2-3-20-4-6-21(7-5-20)30(36)37/h4-9,11-12,15-18,26,28,34H,2-3,10,13-14H2,1H3,(H,36,37)/b12-9+/t26-,28?/m0/s1
PubChem CID	124170712
ChEMBL	N/A
IUPHAR	N/A
BindingDB	202472
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	N/A	BindingDB

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