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GPCR

NameTrace amine-associated receptor 1
SpeciesRattus norvegicus (Rat)
GeneTaar1
SynonymTRAR1
TaR-1
Trace amine receptor 1
TAR1
TA1 receptor
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProtQ923Y9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3833
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL14152682
Molecular formulaC20H19ClN4O2
IUPAC name3-(2-chlorophenyl)-N-[4-[(2S)-morpholin-2-yl]phenyl]-1H-pyrazole-5-carboxamide
Molecular weight382.848
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP2.7
SynonymsN/A
Inchi KeyBNZORDCXIZXJLI-LJQANCHMSA-N
Inchi IDInChI=1S/C20H19ClN4O2/c21-16-4-2-1-3-15(16)17-11-18(25-24-17)20(26)23-14-7-5-13(6-8-14)19-12-22-9-10-27-19/h1-8,11,19,22H,9-10,12H2,(H,23,26)(H,24,25)/t19-/m1/s1
PubChem CID71087844
ChEMBLN/A
IUPHARN/A
BindingDB167461
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki2.6 nMN/ABindingDB

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