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GPCR

NameTrace amine-associated receptor 1
SpeciesRattus norvegicus (Rat)
GeneTaar1
SynonymTRAR1
TaR-1
Trace amine receptor 1
TAR1
TA1 receptor
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProtQ923Y9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3833
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL1991618
Molecular formulaC18H19ClN2O
IUPAC name4-chloro-N-[4-[(3S)-piperidin-3-yl]phenyl]benzamide
Molecular weight314.813
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP3.5
Synonyms1312560-90-9
BDBM250202
Benzamide, 4-chloro-N-[4-(3S)-3-piperidinylphenyl]-
US9452980, 112
ZINC117720460
Inchi KeyBOINLYJULUCZJQ-OAHLLOKOSA-N
Inchi IDInChI=1S/C18H19ClN2O/c19-16-7-3-14(4-8-16)18(22)21-17-9-5-13(6-10-17)15-2-1-11-20-12-15/h3-10,15,20H,1-2,11-12H2,(H,21,22)/t15-/m1/s1
PubChem CID67239798
ChEMBLN/A
IUPHARN/A
BindingDB250202
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki1.8 nMN/ABindingDB

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