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GPCR

NameTrace amine-associated receptor 1
SpeciesRattus norvegicus (Rat)
GeneTaar1
SynonymTRAR1
TaR-1
Trace amine receptor 1
TAR1
TA1 receptor
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProtQ923Y9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3833
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL15578660
Molecular formulaC21H23N5O3
IUPAC name1-(6-ethoxypyridin-2-yl)-N-[4-[(2S)-morpholin-2-yl]phenyl]pyrazole-4-carboxamide
Molecular weight393.447
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP1.7
SynonymsBDBM256427
US9487501, 28
Inchi KeyBOJQVQWGSQTWRG-GOSISDBHSA-N
Inchi IDInChI=1S/C21H23N5O3/c1-2-28-20-5-3-4-19(25-20)26-14-16(12-23-26)21(27)24-17-8-6-15(7-9-17)18-13-22-10-11-29-18/h3-9,12,14,18,22H,2,10-11,13H2,1H3,(H,24,27)/t18-/m1/s1
PubChem CID73442392
ChEMBLN/A
IUPHARN/A
BindingDB256427
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki2.2 nMN/ABindingDB

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