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GPCR

NameThyrotropin-releasing hormone receptor
SpeciesHomo sapiens (Human)
GeneTRHR
SynonymThyroliberin receptor
TRH receptor
TRH-R
TRH-R1
TRH1 receptor
DiseaseUnspecified
Pain
Neurodegenerative disease
Endocrine disease
Cognitive disorders
[ Show all ]
Length398
Amino acid sequenceMENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProtP34981
Protein Data BankN/A
GPCR-HGmod modelP34981
3D structure modelThis predicted structure model is from GPCR-EXP P34981.
BioLiPN/A
Therapeutic Target DatabaseT77796
ChEMBLCHEMBL1810
IUPHAR363
DrugBankBE0008659

Ligand

NameAC1NZ11R
Molecular formulaC19H23N3O5S
IUPAC name3-(diethylsulfamoyl)-N-[(E)-1-(2,4-dihydroxyphenyl)ethylideneamino]benzamide
Molecular weight405.469
Hydrogen bond acceptor7
Hydrogen bond donor3
XlogP2.2
SynonymsN,N-diethyl-3-[[[(1Z)-1-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethyl]amino]carbamoyl]benzenesulfonamide
AC1OA251
SR-01000033403-1
MLS000759728
SMR000369485
[ Show all ]
Inchi KeyBTSAYBKBDLQAJE-DEDYPNTBSA-N
Inchi IDInChI=1S/C19H23N3O5S/c1-4-22(5-2)28(26,27)16-8-6-7-14(11-16)19(25)21-20-13(3)17-10-9-15(23)12-18(17)24/h6-12,23-24H,4-5H2,1-3H3,(H,21,25)/b20-13+
PubChem CID135520033
ChEMBLCHEMBL1994599
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Potency5173.5 nMPubChem BioAssay data setChEMBL

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