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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Free fatty acid receptor 1
Species	Rattus norvegicus (Rat)
Gene	Ffar1
Synonym	FFA1 receptor FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40
Disease	N/A for non-human GPCRs
Length	300
Amino acid sequence	MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVTGYLGTGPGQGTICVTRTPRGTIQK
UniProt	Q8K3T4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1795180
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL17418575
Molecular formula	C34H41FN2O5
IUPAC name	(3S)-3-cyclopropyl-3-[3-[[5-(2-fluoro-5-methoxyphenyl)-6-(3,3,5,5-tetramethylcyclohexyl)oxypyrazin-2-yl]methoxy]phenyl]propanoic acid
Molecular weight	576.709
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	7.5
Synonyms	(3S)-3-Cyclopropyl-3-(3-((5-(2-fluoro-5-methoxyphenyl)-6-(3,3,5,5-tetramethylcyclohexyloxy)pyrazin-2-yl)methoxy)phenyl)propanoic acid BUZDQZLYIICDDD-MHZLTWQESA-N BDBM168161 US9688642, 24
Inchi Key	BUZDQZLYIICDDD-MHZLTWQESA-N
Inchi ID	InChI=1S/C34H41FN2O5/c1-33(2)16-26(17-34(3,4)20-33)42-32-31(28-14-24(40-5)11-12-29(28)35)36-18-23(37-32)19-41-25-8-6-7-22(13-25)27(15-30(38)39)21-9-10-21/h6-8,11-14,18,21,26-27H,9-10,15-17,19-20H2,1-5H3,(H,38,39)/t27-/m0/s1
PubChem CID	118645378
ChEMBL	N/A
IUPHAR	N/A
BindingDB	168161
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	183.0 nM	N/A	BindingDB

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