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GPCR

NameTrace amine-associated receptor 1
SpeciesRattus norvegicus (Rat)
GeneTaar1
SynonymTRAR1
TaR-1
Trace amine receptor 1
TAR1
TA1 receptor
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProtQ923Y9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3833
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL15109736
Molecular formulaC15H15N3O
IUPAC name(2S)-2-(9H-pyrido[2,3-b]indol-6-yl)morpholine
Molecular weight253.305
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP1.7
SynonymsBDBM190639
US9181230, 45
Inchi KeyCSFXCCDZQJPNIN-CQSZACIVSA-N
Inchi IDInChI=1S/C15H15N3O/c1-2-11-12-8-10(14-9-16-6-7-19-14)3-4-13(12)18-15(11)17-5-1/h1-5,8,14,16H,6-7,9H2,(H,17,18)/t14-/m1/s1
PubChem CID71656899
ChEMBLN/A
IUPHARN/A
BindingDB190639
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki1002.1 nMN/ABindingDB

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