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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Trace amine-associated receptor 1
Species	Rattus norvegicus (Rat)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 Trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProt	Q923Y9
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3833
IUPHAR	364
DrugBank	N/A

Ligand

Name	SCHEMBL14150936
Molecular formula	C18H19FN4O4
IUPAC name	4-N-[2-fluoro-4-[(2S)-morpholin-2-yl]phenyl]-6-methoxypyridine-2,4-dicarboxamide
Molecular weight	374.372
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	0.3
Synonyms	US9029370, 120 BDBM158326
Inchi Key	CVAOODJQYWCPPA-OAHLLOKOSA-N
Inchi ID	InChI=1S/C18H19FN4O4/c1-26-16-8-11(7-14(22-16)17(20)24)18(25)23-13-3-2-10(6-12(13)19)15-9-21-4-5-27-15/h2-3,6-8,15,21H,4-5,9H2,1H3,(H2,20,24)(H,23,25)/t15-/m1/s1
PubChem CID	71086950
ChEMBL	N/A
IUPHAR	N/A
BindingDB	158326
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	425.6 nM	N/A	BindingDB

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