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GPCR

NameTrace amine-associated receptor 1
SpeciesRattus norvegicus (Rat)
GeneTaar1
SynonymTRAR1
TaR-1
Trace amine receptor 1
TAR1
TA1 receptor
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProtQ923Y9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3833
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL15578580
Molecular formulaC20H18F3N5O3
IUPAC nameN-[4-[(2S)-morpholin-2-yl]phenyl]-2-[4-(trifluoromethoxy)phenyl]triazole-4-carboxamide
Molecular weight433.391
Hydrogen bond acceptor9
Hydrogen bond donor2
XlogP3.3
SynonymsBDBM240677
US9416127, 14
US9416127, 15
Inchi KeyCVDIRGGTOFSYMF-GOSISDBHSA-N
Inchi IDInChI=1S/C20H18F3N5O3/c21-20(22,23)31-16-7-5-15(6-8-16)28-25-11-17(27-28)19(29)26-14-3-1-13(2-4-14)18-12-24-9-10-30-18/h1-8,11,18,24H,9-10,12H2,(H,26,29)/t18-/m1/s1
PubChem CID73386706
ChEMBLN/A
IUPHARN/A
BindingDB240677
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki0.1 nMN/ABindingDB
Ki3.2 nMN/ABindingDB

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