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GPCR

NameFree fatty acid receptor 4
SpeciesHomo sapiens (Human)
GeneFFAR4
SynonymO3FAR1
G-protein coupled receptor 120
GPR120
G-protein-coupled receptor GT01
G-protein coupled receptor PGR4
[ Show all ]
DiseaseN/A
Length377
Amino acid sequenceMSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
UniProtQ5NUL3
Protein Data BankN/A
GPCR-HGmod modelQ5NUL3
3D structure modelThis predicted structure model is from GPCR-EXP Q5NUL3.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5339
IUPHAR127
DrugBankBE0003399

Ligand

NameSCHEMBL16483416
Molecular formulaC24H34ClNO3
IUPAC name4-[3-(2-chloro-5-cyclobutyloxyphenyl)-3-azaspiro[5.5]undecan-9-yl]butanoic acid
Molecular weight419.99
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP6.8
SynonymsBDBM261590
US9708270, 87
Inchi KeyDBPBTJRSGXBSAC-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H34ClNO3/c25-21-8-7-20(29-19-4-2-5-19)17-22(21)26-15-13-24(14-16-26)11-9-18(10-12-24)3-1-6-23(27)28/h7-8,17-19H,1-6,9-16H2,(H,27,28)
PubChem CID73776981
ChEMBLN/A
IUPHARN/A
BindingDB261590
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC502255.0 nMN/ABindingDB

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