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GPCR

Name5-hydroxytryptamine receptor 2B
SpeciesMus musculus (Mouse)
GeneHtr2b
Synonym5-HT-2B
serotonin receptor 2B
NP75 protein
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
5-HT2F
[ Show all ]
DiseaseN/A for non-human GPCRs
Length479
Amino acid sequenceMASSYKMSEQSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTIHTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETLMRRMSSVGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKFSSTLCFGNSMVENSKFFTKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLTENDGDKAEEQVSYI
UniProtQ02152
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2583
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL14061868
Molecular formulaC21H27N3O2
IUPAC name(2R)-4-[2-(2,3-dihydroindol-1-yl)ethyl]-2-[(2-methylpyridin-3-yl)oxymethyl]morpholine
Molecular weight353.466
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP2.8
SynonymsBDBM186939
US9079895, 26r
Inchi KeyDYMQPSSXRFHPQS-LJQANCHMSA-N
Inchi IDInChI=1S/C21H27N3O2/c1-17-21(7-4-9-22-17)26-16-19-15-23(13-14-25-19)11-12-24-10-8-18-5-2-3-6-20(18)24/h2-7,9,19H,8,10-16H2,1H3/t19-/m1/s1
PubChem CID71062790
ChEMBLN/A
IUPHARN/A
BindingDB186939
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki3169.0 nMN/ABindingDB

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