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GPCR

NameThyrotropin-releasing hormone receptor
SpeciesHomo sapiens (Human)
GeneTRHR
SynonymThyroliberin receptor
TRH receptor
TRH-R
TRH-R1
TRH1 receptor
DiseaseUnspecified
Pain
Neurodegenerative disease
Endocrine disease
Cognitive disorders
[ Show all ]
Length398
Amino acid sequenceMENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProtP34981
Protein Data BankN/A
GPCR-HGmod modelP34981
3D structure modelThis predicted structure model is from GPCR-EXP P34981.
BioLiPN/A
Therapeutic Target DatabaseT77796
ChEMBLCHEMBL1810
IUPHAR363
DrugBankBE0008659

Ligand

Name3-hydroxy-4-((E)-{[(5-methoxy-1-methyl-1H-indol-2-yl)carbonyl]hydrazono}methyl)-2-naphthoic acid
Molecular formulaC23H19N3O5
IUPAC name3-hydroxy-4-[(E)-[(5-methoxy-1-methylindole-2-carbonyl)hydrazinylidene]methyl]naphthalene-2-carboxylic acid
Molecular weight417.421
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP4.2
SynonymsAKOS002123818
MLS001202322
4-[[2-(5-methoxy-1-methylindole-2-carbonyl)hydrazinyl]methylidene]-3-oxonaphthalene-2-carboxylic acid
SR-01000103304
MolPort-007-945-927
[ Show all ]
Inchi KeyGBLPGGPIXKBWGV-WYMPLXKRSA-N
Inchi IDInChI=1S/C23H19N3O5/c1-26-19-8-7-15(31-2)9-14(19)11-20(26)22(28)25-24-12-18-16-6-4-3-5-13(16)10-17(21(18)27)23(29)30/h3-12,27H,1-2H3,(H,25,28)(H,29,30)/b24-12+
PubChem CID135616999
ChEMBLCHEMBL3195304
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Potency18356.4 nMPubChem BioAssay data setChEMBL
Potency20596.2 nMPubChem BioAssay data setChEMBL

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