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GPCR

NameP2Y purinoceptor 1
SpeciesMeleagris gallopavo (Wild turkey)
GeneP2RY1
Synonym6H1 orphan receptor
ADP receptor
P2Y1
Purinergic receptor
DiseaseN/A for non-human GPCRs
Length362
Amino acid sequenceMTEALISAALNGTQPELLAGGWAAGNASTKCSLTKTGFQFYYLPTVYILVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTGVRRNKTITCYDTTADEYLRSYFVYSMCTTVFMFCIPFIVILGCYGLIVKALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDFQTPQMCAFNDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKSSRRSEPNVQSKSEEMTLNILTEYKQNGDTSL
UniProtP49652
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5720
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL288993
Molecular formulaC10H15N5O8P2S
IUPAC name[5-(6-aminopurin-9-yl)-2-(phosphonooxymethyl)thiolan-3-yl] dihydrogen phosphate
Molecular weight427.265
Hydrogen bond acceptor13
Hydrogen bond donor5
XlogP-2.9
SynonymsBDBM50076472
Phosphoric acid mono-[5-(6-amino-purin-9-yl)-2-phosphonooxymethyl-tetrahydro-thiophen-3-yl] ester
Inchi KeyHEYHWCIASKGSFO-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H15N5O8P2S/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(23-25(19,20)21)6(26-7)2-22-24(16,17)18/h3-7H,1-2H2,(H2,11,12,13)(H2,16,17,18)(H2,19,20,21)
PubChem CID44289593
ChEMBLN/A
IUPHARN/A
BindingDB50076472
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.

Experimental Data

ParameterValueReferenceDatabase source
EC5012200.0 nMPMID10229631BindingDB

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