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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanocortin receptor 3
Species	Mus musculus (Mouse)
Gene	Mc3r
Synonym	gamma-MSH receptor MC3 receptor MC3-R melanocortin receptor 3
Disease	N/A for non-human GPCRs
Length	323
Amino acid sequence	MNSSCCLSSVSPMLPNLSEHPAAPPASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIAVINSDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAIDRYVTIFYALRYHSIMTVRKALTLIGVIWVCCGICGVMFIIYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAVLPPAGVVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNSMNLG
UniProt	P33033
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4774
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL448536
Molecular formula	C35H42N12O5
IUPAC name	(2S)-2-[[(2R)-2-[[(2S)-2-acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-cyanophenyl)propanoyl]amino]-N-[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
Molecular weight	710.8
Hydrogen bond acceptor	8
Hydrogen bond donor	9
XlogP	-0.3
Synonyms	Ac-His-DPhe(pCN)-Arg-Trp-NH2 BDBM50252896
Inchi Key	DBWQPEKZJYCIEE-ZXYZSCNASA-N
Inchi ID	InChI=1S/C35H42N12O5/c1-20(48)44-30(15-24-18-40-19-43-24)34(52)47-29(13-21-8-10-22(16-36)11-9-21)33(51)45-27(7-4-12-41-35(38)39)32(50)46-28(31(37)49)14-23-17-42-26-6-3-2-5-25(23)26/h2-3,5-6,8-11,17-19,27-30,42H,4,7,12-15H2,1H3,(H2,37,49)(H,40,43)(H,44,48)(H,45,51)(H,46,50)(H,47,52)(H4,38,39,41)/t27-,28-,29+,30-/m0/s1
PubChem CID	25108141
ChEMBL	CHEMBL448536
IUPHAR	N/A
BindingDB	50252896
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	240.0 nM	PMID18800761	BindingDB,ChEMBL
FC	2.0 -	PMID18800761	ChEMBL

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