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GPCR

NameFree fatty acid receptor 4
SpeciesHomo sapiens (Human)
GeneFFAR4
SynonymO3FAR1
G-protein coupled receptor 120
GPR120
G-protein-coupled receptor GT01
G-protein coupled receptor PGR4
[ Show all ]
DiseaseN/A
Length377
Amino acid sequenceMSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
UniProtQ5NUL3
Protein Data BankN/A
GPCR-HGmod modelQ5NUL3
3D structure modelThis predicted structure model is from GPCR-EXP Q5NUL3.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5339
IUPHAR127
DrugBankBE0003399

Ligand

NameSCHEMBL16482930
Molecular formulaC19H25F2NO3
IUPAC name2-[3-(2,5-difluoro-4-methoxyphenyl)-3-azaspiro[5.5]undecan-9-yl]acetic acid
Molecular weight353.41
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP4.5
SynonymsBDBM261510
US9708270, 6
Inchi KeyHMGKHLBSNZALKC-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H25F2NO3/c1-25-17-12-14(20)16(11-15(17)21)22-8-6-19(7-9-22)4-2-13(3-5-19)10-18(23)24/h11-13H,2-10H2,1H3,(H,23,24)
PubChem CID117886637
ChEMBLN/A
IUPHARN/A
BindingDB261510
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC502420.0 nMN/ABindingDB

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