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GPCR

Name5-hydroxytryptamine receptor 2B
SpeciesMus musculus (Mouse)
GeneHtr2b
Synonym5-HT-2B
serotonin receptor 2B
NP75 protein
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
5-HT2F
[ Show all ]
DiseaseN/A for non-human GPCRs
Length479
Amino acid sequenceMASSYKMSEQSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTIHTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETLMRRMSSVGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKFSSTLCFGNSMVENSKFFTKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLTENDGDKAEEQVSYI
UniProtQ02152
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2583
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL14060090
Molecular formulaC22H29N3O2
IUPAC name(2R)-4-[2-(2,3-dihydroindol-1-yl)ethyl]-2-[(2,4-dimethylpyridin-3-yl)oxymethyl]morpholine
Molecular weight367.493
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP3.2
SynonymsBDBM186945
US9079895, 29r
Inchi KeyHPLSCEVPHLQHEB-HXUWFJFHSA-N
Inchi IDInChI=1S/C22H29N3O2/c1-17-7-9-23-18(2)22(17)27-16-20-15-24(13-14-26-20)11-12-25-10-8-19-5-3-4-6-21(19)25/h3-7,9,20H,8,10-16H2,1-2H3/t20-/m1/s1
PubChem CID71061585
ChEMBLN/A
IUPHARN/A
BindingDB186945
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki1326.0 nMN/ABindingDB

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