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GPCR

NameFree fatty acid receptor 1
SpeciesRattus norvegicus (Rat)
GeneFfar1
SynonymFFA1 receptor
FFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
DiseaseN/A for non-human GPCRs
Length300
Amino acid sequenceMDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVTGYLGTGPGQGTICVTRTPRGTIQK
UniProtQ8K3T4
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1795180
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL17418658
Molecular formulaC27H27FN2O4
IUPAC name(3S)-3-cyclopropyl-3-[3-[[6-cyclopropyl-5-(2-fluoro-5-methoxyphenyl)pyrazin-2-yl]methoxy]phenyl]propanoic acid
Molecular weight462.521
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP4.3
SynonymsBDBM168181
US9688642, 39
(3S)-3-Cyclopropyl-3-(3-((6-cyclopropyl-5-(2-fluoro-5-methoxyphenyl)pyrazin-2-yl)methoxy)phenyl)propanoic acid
HWZPREYQYNXWKH-QFIPXVFZSA-N
Inchi KeyHWZPREYQYNXWKH-QFIPXVFZSA-N
Inchi IDInChI=1S/C27H27FN2O4/c1-33-20-9-10-24(28)23(12-20)27-26(17-7-8-17)30-19(14-29-27)15-34-21-4-2-3-18(11-21)22(13-25(31)32)16-5-6-16/h2-4,9-12,14,16-17,22H,5-8,13,15H2,1H3,(H,31,32)/t22-/m0/s1
PubChem CID118645455
ChEMBLN/A
IUPHARN/A
BindingDB168181
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50104.0 nMN/ABindingDB

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