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GPCR

NameMu-type opioid receptor
SpeciesHomo sapiens (Human)
GeneOPRM1
SynonymhMOP
M-OR-1
MOP
opioid receptor, mu 1
opioid receptor
[ Show all ]
DiseaseDiarrhea
Inflammatory disease
Pain
Major depressive disorder
Migraine
[ Show all ]
Length400
Amino acid sequenceMDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProtP35372
Protein Data BankN/A
GPCR-HGmod modelP35372
3D structure modelThis predicted structure model is from GPCR-EXP P35372.
BioLiPN/A
Therapeutic Target DatabaseT47768
ChEMBLCHEMBL233
IUPHAR319
DrugBankBE0000770

Ligand

NameCHEMBL438965
Molecular formulaC25H25ClN2
IUPAC name5-chloro-2-methyl-3-[1-(naphthalen-1-ylmethyl)piperidin-4-yl]-1H-indole
Molecular weight388.939
Hydrogen bond acceptor1
Hydrogen bond donor1
XlogP6.4
SynonymsSCHEMBL14280680
AAVKSWRCTYHNEP-UHFFFAOYSA-N
BDBM50185795
5-chloro-2-methyl-3-(1-(naphthalen-1-ylmethyl)piperidin-4-yl)-1H-indole
5-chloro-2-methyl-3-(1-naphthalen-1-ylmethyl-piperidin-4-yl)-1H-indole
Inchi KeyAAVKSWRCTYHNEP-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H25ClN2/c1-17-25(23-15-21(26)9-10-24(23)27-17)19-11-13-28(14-12-19)16-20-7-4-6-18-5-2-3-8-22(18)20/h2-10,15,19,27H,11-14,16H2,1H3
PubChem CID44413423
ChEMBLCHEMBL438965
IUPHARN/A
BindingDB50185795
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki880.0 nMPMID16632355BindingDB,ChEMBL

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