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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesRattus norvegicus (Rat)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length406
Amino acid sequenceMDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProtQ62758
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4317
IUPHAR9
DrugBankN/A

Ligand

Namecisapride
Molecular formulaC23H29ClFN3O4
IUPAC name4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide
Molecular weight465.95
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP3.4
SynonymsCisapride prodrug (oral, ECLYPS), ProCor Pharmaceuticals
D00274
DTXSID3022825
HMS3370F16
104860-73-3
[ Show all ]
Inchi KeyDCSUBABJRXZOMT-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)
PubChem CID2769
ChEMBLCHEMBL1729
IUPHAR240
BindingDB50005836
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5054.7 nMPMID16451077ChEMBL
EC5055.0 nM, PMID16451077, Bioorg. Med. Chem. Lett., (1992) 2:12:1613BindingDB,ChEMBL
ED5054.7 nMPMID1573641ChEMBL
Ki10.0 nMPMID9225293BindingDB
Ki10.0 - 158.489 nMPMID8813606, PMID9225293IUPHAR
Ki25.0 nMPMID8813606BindingDB
Ki79.43 nMPMID9225293BindingDB
Ki122.0 nMPMID7796807, PMID8813606BindingDB
Ki125.89 nMPMID9349523BindingDB
Ki158.48 nMPMID9225293BindingDB
Relaxation7.0 %PMID9599243ChEMBL
Relaxation20.3 %PMID9599243ChEMBL

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