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GPCR

NameAlpha-1D adrenergic receptor
SpeciesMus musculus (Mouse)
GeneAdra1d
Synonymalpha1D-AR
alpha1D-adrenoceptor
alpha1a/d-adrenoceptor
alpha1A/D
alpha1A-adrenoceptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length562
Amino acid sequenceMTFRDILSVTFEGPRASSSTGGSGAGGGAGTVGPEGPAVGGVPGATGGSAVVGTGSGEDNQSSTAEAGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWPFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGNPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWPSLRPPLASLDRRPALRLCPQPAHRTPRGSPSPHCTPRPGLRRHAGGAGFGLRPSKASLRLREWRLLGPLQRPTTQLRAKVSSLSHKFRSGGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDLSNLRETDI
UniProtP97714
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2130
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL15746097
Molecular formulaC22H25ClN2O3
IUPAC name2-[(2R)-2-[(3-chlorophenoxy)methyl]morpholin-4-yl]-1-(2-methyl-2,3-dihydroindol-1-yl)ethanone
Molecular weight400.903
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP3.8
SynonymsBDBM186963
US9079895, 65
Inchi KeyXRYWJXIFEBMFIK-OTOKDRCRSA-N
Inchi IDInChI=1S/C22H25ClN2O3/c1-16-11-17-5-2-3-8-21(17)25(16)22(26)14-24-9-10-27-20(13-24)15-28-19-7-4-6-18(23)12-19/h2-8,12,16,20H,9-11,13-15H2,1H3/t16?,20-/m1/s1
PubChem CID90181065
ChEMBLN/A
IUPHARN/A
BindingDB186963
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMN/ABindingDB

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