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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Rattus norvegicus (Rat)
Gene	Htr2b
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT-2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F {ECO:0000303\|PubMed:1331748} Stomach fundus serotonin receptor {ECO:0000303\|PubMed:1505525} [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProt	P30994
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL323
IUPHAR	7
DrugBank	N/A

Ligand

Name	2,4,6-TRIMETHOXYAMPHETAMINE
Molecular formula	C12H19NO3
IUPAC name	1-(2,4,6-trimethoxyphenyl)propan-2-amine
Molecular weight	225.288
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	1.6
Synonyms	BC4183730 SCHEMBL394380 (d,l)-2,4,6-Trimethoxyamphetamine 22199-16-2 benzeneethanamine, 2,4,6-trimethoxy-alpha-methyl- DDGNOUVDFKXADP-UHFFFAOYSA-N 1-Methyl-2-(2,4,6-trimethoxyphenyl)ethylamine # ACM15402796 Benzenethanamine, 2,4,6-trimethoxy-.alpha.-methyl-(.+/-.)- Phenethylamine, 2,4,6-trimethoxy-a-methyl- (6CI,8CI) (+/-)-2,4,6-Trimethoxyamphetamine 2,4,6-Trimethoxyamphetamine, DL- BDBM50164328 CHEMBL34108 TMA-6 1-(2,4,6-trimethoxyphenyl)propan-2-amine Benzeneethanamine,2,4,6-trimethoxy-.alpha.-methyl-(.+/-.)- EN300-243846 15402-79-6 AKOS009377303 Benzenethanamine, 2,4,6-trimethoxy-alpha-methyl-, (+-)- Phenethylamine, 2,4,6-trimethoxy-alpha-methyl- (+/-)1-Methyl-2-(2,4,6-trimethoxy-phenyl)-ethylamine 2,4,6-Trimethoxyphenylisopropylamine Benzeneethanamine, 2,4,6-trimethoxy-a-methyl- (9CI) CTK4C8078 1-Methyl-2-(2,4,6-trimethoxy-phenyl)-ethylamine AC1L1KR4 Benzeneethanamine,2,4,6-trimethoxy-a-methyl- J273.469I [ Show all ]
Inchi Key	DDGNOUVDFKXADP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H19NO3/c1-8(13)5-10-11(15-3)6-9(14-2)7-12(10)16-4/h6-8H,5,13H2,1-4H3
PubChem CID	31015
ChEMBL	CHEMBL34108
IUPHAR	N/A
BindingDB	50164328
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	524.81 nM	PMID7310818	BindingDB,ChEMBL

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