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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Adenosine receptor A3
Species	Homo sapiens (Human)
Gene	ADORA3
Synonym	ARA3 Adenosine receptor A3 A3AR A3 receptor TGPCR1
Disease	Cerebrovascular ischaemia Malaria Ischemia Inflammation Hepatocellular carcinoma; Hepatitis C virus infection Glaucoma Cancer [ Show all ]
Length	318
Amino acid sequence	MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
UniProt	P0DMS8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T36059
ChEMBL	CHEMBL256
IUPHAR	21
DrugBank	BE0000354

Ligand

Name	CHEMBL107637
Molecular formula	C17H14N4
IUPAC name	2-(2-methylphenyl)pyrazolo[3,4-c]quinolin-4-amine
Molecular weight	274.327
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.5
Synonyms	2-o-Tolyl-2H-pyrazolo[3,4-c]quinolin-4-ylamine 2-(2-Methylphenyl)-2H-pyrazolo[3,4-c]quinoline-4-amine BDBM50091111
Inchi Key	AHOSTJOZMPTPLO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H14N4/c1-11-6-2-5-9-15(11)21-10-13-12-7-3-4-8-14(12)19-17(18)16(13)20-21/h2-10H,1H3,(H2,18,19)
PubChem CID	10492556
ChEMBL	CHEMBL107637
IUPHAR	N/A
BindingDB	50091111
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3600.0 nM	PMID10956220	BindingDB,ChEMBL

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