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Name | Muscarinic acetylcholine receptor M3 |
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Species | Homo sapiens (Human) |
Gene | CHRM3 |
Synonym | cholinergic receptor cholinergic receptor, muscarinic 3 cholinergic receptor, muscarinic 3, cardiac Chrm-3 HM4 [ Show all ] |
Disease | Urinary incontinence Overactive bladder Overactive bladder disorder Postoperative nausea and vomiting Respiratory disease [ Show all ] |
Length | 590 |
Amino acid sequence | MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL |
UniProt | P20309 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | T67684 |
ChEMBL | CHEMBL245 |
IUPHAR | 15 |
DrugBank | BE0000045 |
Name | 1-(4-Bromobenzyl)indole-2,3-dione |
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Molecular formula | C15H10BrNO2 |
IUPAC name | 1-[(4-bromophenyl)methyl]indole-2,3-dione |
Molecular weight | 316.154 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 0 |
XlogP | 2.8 |
Synonyms | ZINC2454837 1-[(4-bromophenyl)methyl]indole-2,3-dione AH-034/08903023 EN300-70451 SR-01000395993 [ Show all ] |
Inchi Key | DELLOEULSHGYCG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2 |
PubChem CID | 3008304 |
ChEMBL | CHEMBL523685 |
IUPHAR | 7632 |
BindingDB | 50258439 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
%max | 65.5 % | PMID19438238 | ChEMBL |
EC50 | 6380.0 nM | PMID19438238 | BindingDB,IUPHAR,ChEMBL |
EC50 | 6400.0 nM | PMID22148748, PMID20801651, PMID20004578 | BindingDB,ChEMBL |
Emax | 66.0 % | PMID22148748 | ChEMBL |
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