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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thromboxane A2 receptor
Species	Rattus norvegicus (Rat)
Gene	Tbxa2r
Synonym	prostanoid TP receptor TP receptor TXA2-R TXR2
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MWLNSTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLDWRATDPGCRLCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGTLGLLPLLGLGRYSVQYPGSWCFLTLGAERGDVAFGLMFALLGSVSVGLSLLLNTVSVATLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPVMSPSGQLLRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPTQAMLSGP
UniProt	P34978
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3156
IUPHAR	346
DrugBank	N/A

Ligand

Name	DAZMEGREL
Molecular formula	C16H17N3O2
IUPAC name	3-[3-(imidazol-1-ylmethyl)-2-methylindol-1-yl]propanoic acid
Molecular weight	283.331
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	1.5
Synonyms	Dazmegrel [USAN:INN:BAN] FT-0746556 SR-01000082437 UK-38,485 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-Indole-1-propanoic acid 76894-77-4 DSSTox_CID_26281 MolPort-002-320-893 STK094650 ZINC35877948 3-(Imidazol-1-ylmethyl)-2-methylindole-1-propionic acid AKOS005395464 D03661 Dazmegrel (USAN/INN) DTXSID9046281 Oprea1_040141 UK 38,485 1H-Indole-1-propanoic acid, 3-(1H-imidazol-1-ylmethyl)-2-methyl- 3-[3-(imidazolylmethyl)-2-methylindolyl]propanoic acid CBDivE_000516 Dazmegrelum LS-177314 SR-01000082437-1 UK-38485 3-(1H-imidazole-1-yl-methyl)-2-methyl-1H-indole-1-propanoic acid AC1L1F59 CHEMBL283656 DA-03506 DSSTox_GSID_46281 NCGC00160660-01 Tox21_111966 3-[3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indol-1-yl]propanoic acid BDBM50000317 Dazmegrel [USAN:BAN:INN] EU-0045204 SCHEMBL154037 UK 38485 1H-Indole-1-propanoicacid, 3-(1H-imidazol-1-ylmethyl)-2-methyl- 31340R8PVU CCG-20521 Dazmegrelum [Latin] MCULE-1200400346 ST50898364 UNII-31340R8PVU 3-(3-Imidazol-1-ylmethyl-2-methyl-indol-1-yl)-propionic acid AC1Q2FAS CTK2H7526 DSSTox_RID_81507 NCGC00160660-02 Tox21_111966_1 3-[3-(imidazol-1-ylmethyl)-2-methylindol-1-yl]propanoic acid CAS-76894-77-4 [ Show all ]
Inchi Key	DEQLGSOHGTZKFB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H17N3O2/c1-12-14(10-18-9-7-17-11-18)13-4-2-3-5-15(13)19(12)8-6-16(20)21/h2-5,7,9,11H,6,8,10H2,1H3,(H,20,21)
PubChem CID	53555
ChEMBL	CHEMBL283656
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	<1000.0 nM	Bioorg. Med. Chem. Lett., (1996) 6:14:1691	ChEMBL

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