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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | cinnarizine |
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Molecular formula | C26H28N2 |
IUPAC name | 1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine |
Molecular weight | 368.524 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 0 |
XlogP | 5.8 |
Synonyms | Prestwick2_000278 Cinnarizinum 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine Denapol 1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine [ Show all ] |
Inchi Key | DERZBLKQOCDDDZ-JLHYYAGUSA-N |
Inchi ID | InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+ |
PubChem CID | 1547484 |
ChEMBL | CHEMBL43064 |
IUPHAR | N/A |
BindingDB | 50017657 |
DrugBank | DB00568 |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
IC50 | 776.0 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
Ki | 259.0 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
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