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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameD(1B) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD5
SynonymD(5) dopamine receptor
Dopamine D5 receptor
Gpcr1
D(1B) dopamine receptor
dopamine receptor 5
[ Show all ]
DiseaseSchizophrenia
Solid tumours
Length477
Amino acid sequenceMLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
UniProtP21918
Protein Data BankN/A
GPCR-HGmod modelP21918
3D structure modelThis predicted structure model is from GPCR-EXP P21918.
BioLiPN/A
Therapeutic Target DatabaseT46828
ChEMBLCHEMBL1850
IUPHAR218
DrugBankBE0004889, BE0000145

Ligand

Namecinnarizine
Molecular formulaC26H28N2
IUPAC name1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine
Molecular weight368.524
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP5.8
SynonymsStugeron
298-57-7
Dimitronal
Stutgin
Dimitron
[ Show all ]
Inchi KeyDERZBLKQOCDDDZ-JLHYYAGUSA-N
Inchi IDInChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+
PubChem CID1547484
ChEMBLCHEMBL43064
IUPHARN/A
BindingDB50017657
DrugBankDB00568

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
N/A N/ADrugBank

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