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GPCR

NameP2Y purinoceptor 2
SpeciesHomo sapiens (Human)
GeneP2RY2
SynonymPurinergic receptor
purinergic receptor P2Y
P2Y2 receptor
P2Y2
P2Y purinoceptor 2
[ Show all ]
DiseaseDry eye disease
Constipation
Cystic fibrosis
Lung cancer
Length377
Amino acid sequenceMAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL
UniProtP41231
Protein Data BankN/A
GPCR-HGmod modelP41231
3D structure modelThis predicted structure model is from GPCR-EXP P41231.
BioLiPN/A
Therapeutic Target DatabaseT93515
ChEMBLCHEMBL4398
IUPHAR324
DrugBankBE0002401

Ligand

NameCHEMBL215911
Molecular formulaC9H15N3O11P2
IUPAC name[(2R,3S,4R,5R)-4-amino-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
Molecular weight403.177
Hydrogen bond acceptor12
Hydrogen bond donor6
XlogP-7.3
Synonyms(2R,3R,4S,5R)-1-(3-amino-5-(diphosphoryloxymethyl)-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
BDBM50194163
Inchi KeyDEYDGUCDMRYBLU-XVFCMESISA-N
Inchi IDInChI=1S/C9H15N3O11P2/c10-6-7(14)4(3-21-25(19,20)23-24(16,17)18)22-8(6)12-2-1-5(13)11-9(12)15/h1-2,4,6-8,14H,3,10H2,(H,19,20)(H,11,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
PubChem CID16082708
ChEMBLCHEMBL215911
IUPHARN/A
BindingDB50194163
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

ParameterValueReferenceDatabase source
Ratio EC501.3 -PMID16942026ChEMBL

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