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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Mu-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRM1
Synonym	hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor MOPr MOR-1 Mu opiate receptor Mu opioid receptor mu receptor OP3 [ Show all ]
Disease	Diarrhea Inflammatory disease Pain Major depressive disorder Migraine Mild pain Moderate-to-severe acute pain Opioid-induced constipation Opiate dependence Urinary incontinence Movement disorder Obesity Non-small cell lung cancer Systemic pain Headache Analgesia Anesthesia Asthma Cancer pain Chronic pain Constipation Diabetic neuropathy Unspecified Gastrointestinal disease Gastrointestinal disease; Pain General anesthesia Narcotic depression [ Show all ]
Length	400
Amino acid sequence	MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P35372
Protein Data Bank	N/A
GPCR-HGmod model	P35372
3D structure model	This predicted structure model is from GPCR-EXP P35372.
BioLiP	N/A
Therapeutic Target Database	T47768
ChEMBL	CHEMBL233
IUPHAR	319
DrugBank	BE0000770

Ligand

Name	Piribedil mesylate
Molecular formula	C17H22N4O5S
IUPAC name	2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine;methanesulfonic acid
Molecular weight	394.446
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	None
Synonyms	2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine; methanesulfonic acid C16H18N4O2.CH4O3S I14-7668 Piribedil monomethylsulfonate 52293-23-9 DTXSID30200314 Opera_ID_1848 Pyrimidine, 2-(4-piperonyl-1-piperazinyl)-, methanesulfonate 2-(4-(1,3-Benzodioxol-5-ylmethyl)piperazinyl)pyrimidinium methanesulphonate ACM52293239 HMS2230N20 Piribedil methylsulfonate UNII-1U37NGM6KK 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazinyl]pyrimidinium methanesulfonate LS-135518 Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-, monomethanesulfonate 1-(3,4-METHYLENEDIOXYBENZYL)-4-(2-PYRIMIDYL)-PIPERAZINE MONO(METHANESULFONATE) SALT A823101 EINECS 257-818-8 SCHEMBL1652330 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine; methanesulfonic acid AKOS015918393 HMS3373M21 Piribedil monomethanesulfonate 3605-01-4 (Parent) CHEMBL1468572 MLS000028838 Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-, monomethanesulfonate (9CI) 1U37NGM6KK AC1L5518 ET 495 methanesulfonate Piribedil methanesulfonate SMR000058709 [ Show all ]
Inchi Key	DEZKFCIOSKCCHK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H18N4O2.CH4O3S/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14;1-5(2,3)4/h1-5,10H,6-9,11-12H2;1H3,(H,2,3,4)
PubChem CID	198284
ChEMBL	CHEMBL1468572
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	92454.0 nM	PubChem BioAssay data set	ChEMBL

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