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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesRattus norvegicus (Rat)
GeneHtr7
SynonymGPRFO
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
5-HTx
5-HT7 receptor
5-HT7
[ Show all ]
DiseaseN/A for non-human GPCRs
Length448
Amino acid sequenceMMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProtP32305
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3223
IUPHAR12
DrugBankN/A

Ligand

NameCHEMBL273452
Molecular formulaC23H30N2O
IUPAC name1-[4-(4-propan-2-ylpiperidin-1-yl)butyl]benzo[cd]indol-2-one
Molecular weight350.506
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP5.1
SynonymsBDBM50403762
1-[4-(4-Isopropylpiperidino)butyl]-1,2-dihydrobenzo[cd]indole-2-one
Inchi KeyDFEGJCFQOIKENM-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H30N2O/c1-17(2)18-11-15-24(16-12-18)13-3-4-14-25-21-10-6-8-19-7-5-9-20(22(19)21)23(25)26/h5-10,17-18H,3-4,11-16H2,1-2H3
PubChem CID11382534
ChEMBLCHEMBL273452
IUPHARN/A
BindingDB50403762
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki199.53 nMPMID10843226, PMID14667218ChEMBL
Ki200.0 nMPMID10843226BindingDB

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