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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H2 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH2
Synonym	Gastric receptor I H2R HH2R
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProt	P47747
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2882
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL33996
Molecular formula	C13H15N5O2
IUPAC name	(E)-1-N-methyl-1-N'-[3-(5-methyl-1H-imidazol-4-yl)phenyl]-2-nitroethene-1,1-diamine
Molecular weight	273.296
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	2.8
Synonyms	BDBM50404957
Inchi Key	AHTVWBASZDVUGP-KPKJPENVSA-N
Inchi ID	InChI=1S/C13H15N5O2/c1-9-13(16-8-15-9)10-4-3-5-11(6-10)17-12(14-2)7-18(19)20/h3-8,14,17H,1-2H3,(H,15,16)/b12-7+
PubChem CID	44280956
ChEMBL	CHEMBL33996
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	15848.9 nM	PMID6131129	ChEMBL

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