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GPCR

NameRelaxin receptor 2
SpeciesHomo sapiens (Human)
GeneRXFP2
SynonymRXFPR2
RXFP2
relaxin/insulin like family peptide receptor 2
relaxin receptor 2
Relaxin family peptide receptor 2
[ Show all ]
DiseaseN/A
Length754
Amino acid sequenceMIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSVILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKKSLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS
UniProtQ8WXD0
Protein Data Bank2m96
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 2m96.
BioLiPBL0278456
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1628482
IUPHARN/A
DrugBankN/A

Ligand

NameMLS000417683
Molecular formulaC22H24N4O3S2
IUPAC nameN-(2-methyl-5-piperidin-1-ylsulfonylphenyl)-2-quinazolin-4-ylsulfanylacetamide
Molecular weight456.579
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP3.6
Synonyms721890-15-9
AC1NOC55
AKOS000870728
BDBM114351
CHEMBL1519696
[ Show all ]
Inchi KeyDGAKDVIAOVPIHJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H24N4O3S2/c1-16-9-10-17(31(28,29)26-11-5-2-6-12-26)13-20(16)25-21(27)14-30-22-18-7-3-4-8-19(18)23-15-24-22/h3-4,7-10,13,15H,2,5-6,11-12,14H2,1H3,(H,25,27)
PubChem CID5110655
ChEMBLCHEMBL1519696
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Potency15440.5 nMPubChem BioAssay data setChEMBL

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