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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1992767
Molecular formulaC24H15BrN4O
IUPAC name3-[[5-bromo-2-(naphthalen-1-ylmethyl)-3-oxopyridazin-4-yl]-cyanomethyl]benzonitrile
Molecular weight455.315
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.2
SynonymsSR-02000001922
SR-02000001922-1
Inchi KeyDHGDPGJTVBAFBB-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H15BrN4O/c25-22-14-28-29(15-19-9-4-7-17-6-1-2-10-20(17)19)24(30)23(22)21(13-27)18-8-3-5-16(11-18)12-26/h1-11,14,21H,15H2
PubChem CID53384717
ChEMBLCHEMBL1992767
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50693.0 nMPubChem BioAssay data setChEMBL

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