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GPCR

NameNociceptin receptor
SpeciesHomo sapiens (Human)
GeneOPRL1
SynonymMOR-C
KOR-3
NOP receptor
N/OFQ receptor
nociceptin receptor ORL1
[ Show all ]
DiseasePsychiatric disorder
Pain; Stress
Pain
Major depressive disorder
Inflammatory disease
[ Show all ]
Length370
Amino acid sequenceMEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
UniProtP41146
Protein Data Bank5dhg, 4ea3, 5dhh
GPCR-HGmod modelP41146
3D structure modelThis structure is from PDB ID 5dhg.
BioLiPBL0328039,BL0328040, BL0227293,BL0227294, BL0328041,BL0328042
Therapeutic Target DatabaseT52921
ChEMBLCHEMBL2014
IUPHAR320
DrugBankBE0002378

Ligand

NameCHEMBL230253
Molecular formulaC23H31NO
IUPAC name4-phenyl-1-(1-phenylhexyl)piperidin-4-ol
Molecular weight337.507
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP5.3
Synonyms4-phenyl-1-(1-phenylhexyl)piperidin-4-ol
D0O7JV
BDBM50210418
Inchi KeyAHZUGQDNSYDLNN-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H31NO/c1-2-3-6-15-22(20-11-7-4-8-12-20)24-18-16-23(25,17-19-24)21-13-9-5-10-14-21/h4-5,7-14,22,25H,2-3,6,15-19H2,1H3
PubChem CID44426810
ChEMBLCHEMBL230253
IUPHARN/A
BindingDB50210418
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity101.0 uMPMID17428659ChEMBL
Ki14.0 nMPMID17428659BindingDB,ChEMBL

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