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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1729987
Molecular formulaC21H21N3O4
IUPAC name5-[(E)-hydroxyiminomethyl]-4-(4-methoxyphenoxy)-2-(4-propan-2-ylphenyl)pyridazin-3-one
Molecular weight379.416
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP3.8
SynonymsN/A
Inchi KeyDHWOMVXPTCGVCE-YDZHTSKRSA-N
Inchi IDInChI=1S/C21H21N3O4/c1-14(2)15-4-6-17(7-5-15)24-21(25)20(16(12-22-24)13-23-26)28-19-10-8-18(27-3)9-11-19/h4-14,26H,1-3H3/b23-13+
PubChem CID46835790
ChEMBLCHEMBL1729987
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5016100.0 nMPubChem BioAssay data setChEMBL

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