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GPCR

NameMelanocyte-stimulating hormone receptor
SpeciesMus musculus (Mouse)
GeneMc1r
SynonymMC1 receptor
MC1-R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Melanocortin receptor 1
MSH-R
DiseaseN/A for non-human GPCRs
Length315
Amino acid sequenceMSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
UniProtQ01727
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4077
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL396655
Molecular formulaC22H27N3O
IUPAC nameN-(2-aminoethyl)-3-(1H-indol-3-yl)-N-(3-phenylpropyl)propanamide
Molecular weight349.478
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP3.1
SynonymsBDBM50217790
N-(2-aminoethyl)-3-(1H-indol-3-yl)-N-(3-phenylpropyl)propanamide
Inchi KeyDIESRRMGUFIAAC-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H27N3O/c23-14-16-25(15-6-9-18-7-2-1-3-8-18)22(26)13-12-19-17-24-21-11-5-4-10-20(19)21/h1-5,7-8,10-11,17,24H,6,9,12-16,23H2
PubChem CID9946358
ChEMBLCHEMBL396655
IUPHARN/A
BindingDB50217790
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki21000.0 nMPMID17618123BindingDB,ChEMBL

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