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GPCR

NameMelanin-concentrating hormone receptor 2
SpeciesHomo sapiens (Human)
GeneMCHR2
SynonymG-protein coupled receptor 145
melanin-concentrating hormone receptor 2
MCHR-2
MCH2R
MCH2 receptor
[ Show all ]
DiseaseN/A
Length340
Amino acid sequenceMNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProtQ969V1
Protein Data BankN/A
GPCR-HGmod modelQ969V1
3D structure modelThis predicted structure model is from GPCR-EXP Q969V1.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5038
IUPHAR281
DrugBankN/A

Ligand

NameCHEMBL209089
Molecular formulaC32H33F2N3O
IUPAC name3-[4-[4-(3-cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]-N-(3,4-difluorophenyl)propanamide
Molecular weight513.633
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP6.5
Synonyms3-[4-(3''-cyano-biphenyl-4-yl)-1-cyclopentyl-piperidin-4-yl]-N-(3,4-difluoro-phenyl)-propionamide
BDBM50186786
Inchi KeyDIRDEJWHHBAMET-UHFFFAOYSA-N
Inchi IDInChI=1S/C32H33F2N3O/c33-29-13-12-27(21-30(29)34)36-31(38)14-15-32(16-18-37(19-17-32)28-6-1-2-7-28)26-10-8-24(9-11-26)25-5-3-4-23(20-25)22-35/h3-5,8-13,20-21,28H,1-2,6-7,14-19H2,(H,36,38)
PubChem CID20608975
ChEMBLCHEMBL209089
IUPHARN/A
BindingDB50186786
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki<3000.0 nMPMID16690312BindingDB,ChEMBL

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