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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Homo sapiens (Human)
Gene	HTR5A
Synonym	5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A 5-HT5A 5HT5- 5-HT5A receptor 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled serotonin receptor 5A [ Show all ]
Disease	N/A
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
UniProt	P47898
Protein Data Bank	N/A
GPCR-HGmod model	P47898
3D structure model	This predicted structure model is from GPCR-EXP P47898.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3426
IUPHAR	10
DrugBank	BE0004688

Ligand

Name	6,8,9-trimethyl-11H-indolo[3,2-c]quinoline
Molecular formula	C18H16N2
IUPAC name	6,8,9-trimethyl-11H-indolo[3,2-c]quinoline
Molecular weight	260.34
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	4.8
Synonyms	AC1NTWDU MolPort-002-848-148 SR-01000877155-2 MCULE-7757854384 AQ-405/42300256 SMR000477820 CHEMBL1710136 ZINC6533766 MLS001182610 BDBM83395 SR-01000877155 cid_5412959 [ Show all ]
Inchi Key	DISDWAOVQQELPK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H16N2/c1-10-8-14-16(9-11(10)2)20-18-13-6-4-5-7-15(13)19-12(3)17(14)18/h4-9,20H,1-3H3
PubChem CID	5412959
ChEMBL	CHEMBL1710136
IUPHAR	N/A
BindingDB	83395
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<92431.0 nM	PubChem BioAssay data set	ChEMBL

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