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GPCR

NamePlatelet-activating factor receptor
SpeciesMus musculus (Mouse)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN
UniProtQ62035
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3993
IUPHAR334
DrugBankN/A

Ligand

NameCHEMBL103694
Molecular formulaC29H34N4O2
IUPAC name1-[4-[(2Z)-2-methoxyimino-1-(2-methylpyridin-3-yl)propyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
Molecular weight470.617
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP4.2
SynonymsBDBM50046014
1-{4-[2-Methoxyimino-1-(2-methyl-pyridin-3-yl)-propyl]-piperazin-1-yl}-3,3-diphenyl-propan-1-one
Inchi KeyDITSWVVVBVIBQL-SXBRIOAWSA-N
Inchi IDInChI=1S/C29H34N4O2/c1-22-26(15-10-16-30-22)29(23(2)31-35-3)33-19-17-32(18-20-33)28(34)21-27(24-11-6-4-7-12-24)25-13-8-5-9-14-25/h4-16,27,29H,17-21H2,1-3H3/b31-23-
PubChem CID44332558
ChEMBLCHEMBL103694
IUPHARN/A
BindingDB50046014
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ID50<3.0 mg.kg-1PMID8411016ChEMBL

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