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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Homo sapiens (Human)
Gene	HTR4
Synonym	5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4
Disease	N/A
Length	388
Amino acid sequence	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProt	Q13639
Protein Data Bank	N/A
GPCR-HGmod model	Q13639
3D structure model	This predicted structure model is from GPCR-EXP Q13639.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1875
IUPHAR	9
DrugBank	BE0000084

Ligand

Name	CHEMBL489412
Molecular formula	C23H29ClN4O5
IUPAC name	2-[4-[[(6-methyl-2-oxo-1H-pyridine-3-carbonyl)amino]methyl]piperidin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate
Molecular weight	476.958
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	2.9
Synonyms	N/A
Inchi Key	AICYJQTUJDSUTM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H29ClN4O5/c1-14-3-4-16(22(30)27-14)21(29)26-13-15-5-7-28(8-6-15)9-10-33-23(31)17-11-18(24)19(25)12-20(17)32-2/h3-4,11-12,15H,5-10,13,25H2,1-2H3,(H,26,29)(H,27,30)
PubChem CID	42625659
ChEMBL	CHEMBL489412
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	10.0 %	PMID19334715	ChEMBL
Emax	10.0 %	PMID19334715	ChEMBL

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