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Name | Beta-3 adrenergic receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Adrb3 |
Synonym | beta3-adrenoceptor beta3-adrenergic receptor Beta-3 adrenoreceptor Beta-3 adrenoceptor ADRB [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 400 |
Amino acid sequence | MAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELGRFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPSLVPSGVFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSYGGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT |
UniProt | P26255 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4031 |
IUPHAR | 30 |
DrugBank | N/A |
Name | CHEMBL57373 |
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Molecular formula | C40H44ClNO7 |
IUPAC name | bis(4-phenylbutyl) 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate |
Molecular weight | 686.242 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 2 |
XlogP | 8.7 |
Synonyms | 5-[(R)-2-[[(R)-beta-Hydroxy-3-chlorophenethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid bis(4-phenylbutyl) ester |
Inchi Key | DJPBEORCLQYGKM-UYHPJTEGSA-N |
Inchi ID | InChI=1S/C40H44ClNO7/c1-29(42-28-35(43)33-19-12-20-34(41)27-33)25-32-21-22-36-37(26-32)49-40(48-36,38(44)46-23-10-8-17-30-13-4-2-5-14-30)39(45)47-24-11-9-18-31-15-6-3-7-16-31/h2-7,12-16,19-22,26-27,29,35,42-43H,8-11,17-18,23-25,28H2,1H3/t29-,35+/m1/s1 |
PubChem CID | 44300324 |
ChEMBL | CHEMBL57373 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Response | 43.0 % | PMID10450954 | ChEMBL |
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