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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Homo sapiens (Human)
Gene	HTR1D
Synonym	Serotonin 1D alpha receptor serotonin receptor 1D HTRL Htr1db 5-HT-1D 5-HT-1D-alpha 5-HT1D 5-HT1D receptor 5-HT1Dalpha 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Gpcr14 HT1DA [ Show all ]
Disease	Acute migraine Epilepsy Migraine headaches Mood disorder Migraine Major depressive disorder Severe mood disorders [ Show all ]
Length	377
Amino acid sequence	MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
UniProt	P28221
Protein Data Bank	N/A
GPCR-HGmod model	P28221
3D structure model	This predicted structure model is from GPCR-EXP P28221.
BioLiP	N/A
Therapeutic Target Database	T11072
ChEMBL	CHEMBL1983
IUPHAR	3
DrugBank	BE0000659

Ligand

Name	CHEMBL361303
Molecular formula	C21H22FN3O
IUPAC name	4-fluoro-N-[1-(1-methylpiperidin-4-yl)indol-6-yl]benzamide
Molecular weight	351.425
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.4
Synonyms	823191-52-2 Benzamide, 4-fluoro-N-[1-(1-methyl-4-piperidinyl)-1H-indol-6-yl]- 4-Fluoro-N-[1-(1-methylpiperidin-4-yl)-1H-indol-6-yl]benzamide CTK3E1015 AKOS030578067 DTXSID70658719 BDBM50156407 4-Fluoro-N-[1-(1-methyl-piperidin-4-yl)-1H-indol-6-yl]-benzamide [ Show all ]
Inchi Key	DKDSMUOEMDNPTM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H22FN3O/c1-24-11-9-19(10-12-24)25-13-8-15-4-7-18(14-20(15)25)23-21(26)16-2-5-17(22)6-3-16/h2-8,13-14,19H,9-12H2,1H3,(H,23,26)
PubChem CID	44395832
ChEMBL	CHEMBL361303
IUPHAR	N/A
BindingDB	50156407
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	140.0 nM	PMID15546719	BindingDB,ChEMBL

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